Orexin-A Levels in Insomnia Patients

Sex: Male

Ages: 18 Years – 65 Years

Healthy volunteers: 1

Enrollment: 60

Sponsor: Muğla Sıtkı Koçman University

Summary

In the pathophysiology of insomnia, the increase of the orexin-A (OXA) peptide released from orexin neurons in the lateral hypothalamus plays an important role. Orexins takes part at the emergence of anesthesia. In the literature, investigators could not attain any studies about the arousal of insomnia patients from anesthesia. In this study, the effect of this peptide on the emergence process from anesthesia was investigated by comparing plasma OXA levels before and after anesthesia in insomnia patients.

Eligibility Criteria

Inclusion Criteria:male patients undergo elective laparoscopic cholecystectomy under general anesthesiaBetween 18-65 ageASA I-IIExclusion Criteria:ASA≥IIIPatients with obstructive sleep apnea syndromeBleeding over 500 mlAllergic to anesthetic agentsPatients with a BMI > 30 kg/m2

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05664295). StuddyBuddy aggregates publicly available trial information.