Feasibility in Identification of Breast Cancer Candidates for Elimination of Axillary Surgery

Conditions: Breast Cancer

Sex: Female

Ages: 18 Years – 70 Years

Phase: NA

Enrollment: 191

Sponsor: Fudan University

Location: China

Summary

Preoperative identification of patients with pathologic complete response or residual disease in axilla can aid in tailoring subsequent axillary surgery including omission of axillary surgery based on tumor biology and response to neoadjuvant chemotherapy.

Eligibility Criteria

Inclusion Criteria:Clinical stage T1-4 N1-3M0 breast cancer at diagnosis (prior to neoadjuvant chemotherapy) by American Joint Committee on Cancer (AJCC) staging 7th editionAged above 18 and below 70 yearsNo other malignancy within 5 years of registration with the exception of basal cell or squamous cell carcinoma of the skin treated with local resection only or carcinoma in situ of the cervixPatients must have had estrogen receptor, progesterone receptor and HER2 status (by immunohistochemistry [IHC] and/or in situ hybridization [ISH]) evaluated on core needle biopsy prior to starting neoadjuvant chemotherapyCompleting all planned cycles and regimens of neoadjuvant chemotherapy followed by axillary surgeryExclusion Criteria:Nonrepresentative core needle biopsy in the breast during neoadjuvant chemotherapyInflammatory breast cancer

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05663021). StuddyBuddy aggregates publicly available trial information.