Leukocyte and Platelet-rich Fibrin (L-PRF) Effects on Alveolar Ridge Preservation. A Randomized Controlled Clinical Trial.

The goal of this clínical trial is to compare in patients needing extraction of anterior teeth the effects of leukocyte-and platelet-rich fibrin (L-PRF) for alveolar ridge preservation versus spontaneous healing. The main questions it aims to answer are:Does L-PRF use as alveolar ridge preservation material diminish volumetric changes in the alveolar ridge produced after tooth extraction and further bone regeneration needs?Does it have any advantage for wound healing and patient-related outcomes? Participants will undergoTooth extractionAlveolar ridge preservation/ spontaneous healingImplant placementResearchers will compare alveolar ridge preservation with L-PRF with spontaneous healing to see if there is an effect on reducing ridge dimensional changes happening after tooth extraction.

Inclusion Criteria:Systemically healthy patients ≥18 years oldNeed for extraction of a tooth in the anterior area (position of second premolar to second premolar in maxilla or mandible) that needs to be replaced by an implant-supported restorationPresence of natural teeth mesially and distally of tooth to be extracted, periodontally healthy (probing depths <5 mm without bleeding on probing).Exclusion Criteria:Systemic conditions affecting bone or soft tissue healingSmokers of more than 10 cigarettes a day or equivalent to cigarettesBreastfeeding or pregnant womenPatients without availability to attend follow-up visits or patients rejecting to sign the informed consent