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Completed
NCT05662475
Effect of Periodontal Treatment on Visfatin, fetuin-a and Sirtuin 1 of Patients With Periodontitis and Type 2 Diabetes
Conditions: Periodontal Diseases, Type 2 Diabetes, Periodontitis
Sex: All
Ages: 31 Years – 81 Years
Healthy volunteers: 1
Phase: NA
Enrollment: 66
Sponsor: Ondokuz Mayıs University
Location: Turkey
Summary
The aim of this study is to determine the concentrations of Visfatin, Fetuin-A and Sirtuin 1 in the gingival crevicular fluid and clinical periodontal parameters in diabetic and systemically healthy individuals and to determine whether non-surgical periodontal treatment had any effect on these biomarkers and periodontal clinical parameters at the end of a 3-month follow-up period.
The hypothesis of our study is that gingival crevicular fluid Visfatin, Fetuin-A and Sirtuin 1 concentrations will change with non-surgical periodontal treatment in type 2 diabetic and systemically healthy individuals and that this change will be associated with diabetes and clinical parameters.
Eligibility Criteria
Inclusion Criteria:Volunteering to participate in the studyTo be over 18 years oldNo periodontal treatment in the last 6 monthsBeing systemically healthy except for type 2 diabetesNot taking medication for any reason except type 2 diabetesHbA1c <7 in controlled Type 2 diabetes groupHbA1c ≥7 in uncontrolled Type 2 diabetes groupNot smoking or drinking alcoholExclusion Criteria:Not volunteering to participate in the studyUnder 18 years of agePeriodontal treatment in the last 6 monthsHaving any systemic disease affecting the periodontal conditionHaving used local or systemic antibiotics in the last 3 monthsUse of anti-inflammatory, steroid drugs in the last 3 monthsTaking vitamin, mineral or antioxidant supplements in the last 3 monthsBeing pregnant or lactatingRegular use of mouthwashSmoking or drinking alcohol
Source: ClinicalTrials.gov (NCT05662475). StuddyBuddy aggregates publicly available trial information.
