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Not Yet Recruiting NCT05660733

Study of the Aortic and Large Arterial Vessel Infections

Conditions: Aortic Infections and Inflammations, Mycotic Aneurysm, Arterial Infections and Inflammations, Prosthetic Infection

Sex: All
Ages: 18 Years – N/A
Enrollment: 500
Sponsor: Central Hospital, Nancy, France

Location: France

Summary

Aortic or large arterial vessel infections are rare but serious infections. Their management is based on French and American expert opinions. The quality of evidence supporting these guidelines is low because most publications on the subject correspond to case series and few interventional studies have been performed to validate their management. However, referral centres for vascular surgery are frequently solicited to give their opinion on patients suffering from mycotic aneurysms. In addition, the last few decades have seen the improvement of vascular surgery techniques allowing the management of more and more patients, often elderly and comorbid. There has therefore been an increase in the incidence of infectious complications associated with this care. It is therefore essential to participate in research on aortic and large arterial vessel infections. For this, a monocentric cohort study seems to be an essential first step to better understand the polymorphism and complexity of these patients.

Eligibility Criteria

Inclusion Criteria:Age ≥ 18 yearsAortic or large arterial vessel infection. The diagnosis is made on a number of criteria in favour of the diagnosis (at least 2 of the following 3 criteria):Compatible clinical presentation: local or general inflammatory signs suggestive of a deep infection (fever, chills, scar discharge, fistula, febrile abdominal pain and low back pain, ...) or per-operative finding of an infection in contact with native or prosthetic vascular tissueAnd/or biological (inflammatory syndrome) and/or imaging evidence (infectious sign on native, bioprosthetic or prosthetic vascular tissue on CT and/or PET scan) in favour of the diagnosisAnd/or microbiological evidence (positive serologies, blood cultures or deep samples in favour of infection)Exclusion Criteria:Patient who objected to participation in this protocol and data collectionPregnant woman, parturient or breastfeeding motherPerson deprived of liberty by a judicial or administrative decision,Person subject to psychiatric care by virtue of articles L.3212-1 and L.3213-1 of the French public health codePerson subject to a legal protection measurePerson unable to give consent

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05660733). StuddyBuddy aggregates publicly available trial information.