Clinical Study of Venetoclax Combined With CACAG Regimen in the Treatment of Newly Diagnosed Acute Myeloid Leukemia

The purpose of this study is to evaluate the efficacy and safety of venetoclax combined with CACAG regimen in the treatment of newly diagnosed acute myeloid leukemia.

Inclusion Criteria:Patients who are able to understand and willing to sign the informed consent form (ICF).All patients should aged 14 to75 years,no gender limitation.Patients who are newly diagnosed with AML.Liver function: ALT and AST≤2.5 times the upper limit of normal ,bilirubin≤2 times the upper limit of normal;Renal function: creatinine ≤the upper limit of normal;Patients without any uncontrolled infections , without organ dysfunction or without severe mental illness;The score of Eastern Cooperative Oncology Group (ECOG) is 0-3,and the predicted survival ≥ 4 months.Patients without severe allergic constitution.Exclusion Criteria:Patients with allergy or contraindication to the study drug;Female patients who are pregnant or breast-feeding.Patients with active infectionPatients with a known history of alcohol or drug addiction on the basis that there could be a higher risk of non-compliance to study treatment;Patients with mental illness or other states unable to comply with the protocol;Less than 6 weeks after surgical operation of important organs.Liver function: ALT and AST>2.5 times the upper limit of normal ,bilirubin>2 times the upper limit of normal;Renal function: creatinine >the upper limit of normal;The patient is not suitable for this clinical trial (poor compliance, substance abuse, etc.)