The KIN-FAST Trial (KIN001 For Accelerated Symptoms Termination) in Non Hospitalized Patients Infected With SARS-CoV-2

Clinical trial on safety and efficacy of KIN001 in non-hospitalized patients with COVID-19.

Inclusion Criteria:Diagnosis of symptomatic COVID-19 of less than 5 days' duration, with at least 1 point in at least 4 items of the symptom evaluation table, and at least 2 points in at least 2 items, OR a minimum total score of 6 pointsDiagnosis of COVID-19 confirmed in the last 48 hours by a positive test for SARS-CoV-2 RNA by RT PCR or a rapid validated antigen test (excluding self-test), in a specimen from the upper respiratory tract, the saliva (antigen test), the lower respiratory tract or an expectorated sputumNo indication that the patient will be hospitalized in the next 48 hours for COVID-19 related reasonsAdult male or female patients aged ≥ 18 yearsFemales must have a negative pregnancy test or must be post-menopausalAble to understand and willing to sign an IRB/IEC approved written informed consent document.Able to understand and be available for daily phone calls to evaluate symptoms.Exclusion Criteria:Patients with an indication for hospitalization (e.g. SpO2 <92%)Patients participating in another clinical trial with a new investigational drug or investigational non-drug treatmentKnown allergy or intolerance to pamapimod or any other ingredient of the IMP or another P38 inhibitorKnown allergy or intolerance of clinical relevance to pioglitazone or any other ingredient of the IMP.Patients where oral administration of pioglitazone is contraindicated (i.e. cardiac failure or history of cardiac failure (NYHA stages I to IV), with hepatic impairment, diabetic ketoacidosis, current bladder cancer or a history of bladder cancer, uninvestigated macroscopic haematuriaAny use of CYP450 2C8 inducers (e.g. rifampicin)Known or suspected active viral (including HIV, hepatitis B, hepatitis C), bacterial, mycobacterial or fungal infection other than COVID-19. Virologic testing not required unless infection is suspected.Pregnant or breastfeeding womenAny uncontrolled concurrent illness that would put the patient at a greater risk or limit compliance with the study requirements as determined at the discretion of the investigatorLiver enzyme elevation more than 3x above normal in the last 4 weeks or at inclusionPatients who are detained or committed to an institution by a law court or by legal authorities (subject is vulnerable, such as deprived of freedom)