Contrast-enhanced vs. B-mode Ultrasound-guided Percutaneous Biopsy of Retroperitoneal Tumors

Conditions: Retroperitoneal Neoplasms

Sex: All

Ages: 18 Years – N/A

Phase: NA

Enrollment: 160

Sponsor: Iuliu Hatieganu University of Medicine and Pharmacy

Location: Romania

Summary

Background: Retroperitoneal tumors are typically large and inhomogeneous, with a variable amount of necrosis within the tumor mass which decreases the diagnostic yield of biopsy (false negative or inadequate).Rationale: Real-time contrast enhancement can highlight the viable tumoral tissue and avoid the necrotic area.Aims: To compare contrast-enhanced ultrasound (CEUS) guidance and conventional (B-mode) ultrasound (US) guidance in terms of diagnostic yield, need for repeat biopsy, and rate of adverse events.Methods: A consecutive series of patients with previously documented retroperitoneal tumors and indications for percutaneous biopsy were randomly assigned to benefit from the standard of practice B-mode US-guided biopsy or CEUS-guided biopsy.The diagnostic accuracy, need for repeat biopsy, and adverse events were noted.

Eligibility Criteria

Inclusion Criteria:All patients with retroperitoneal tumors with indication for percutaneous biopsyExclusion Criteria:Tumors inaccessible for ultrasound guided biopsyStandard contraindications for biopsy (altered coagulation tests, poor performance status)Lack of written informed consent

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Source: ClinicalTrials.gov (NCT05659433). StuddyBuddy aggregates publicly available trial information.