Potential Role of microRNA 410 and BIRC7 Pathways in Unexplained Recurrent Spontaneous Miscarriage

The definition of recurrent spontaneous abortion (RSA) has changed over the years, and most societies now advocate defining RSA as two or three consecutive or discontinuous miscarriages with the same sexual partner before 24 weeks gestationIn recent years, the incidence of this disease has been on the rise, occurring in about 1%- 5% of pregnancy in women at childbearing age, and the success rate of second pregnancy in RSA females has been significantly reduced The etiology of RSA is extremely complex, including anatomical factors, genetic factors, endocrine factors, infectious and immune factors, and pre-thrombosis etiology.However, the cause of the disease is unclear in half of patients and known as unexplained recurrent spontaneous abortion (URSA)

Inclusion Criteria: maternal age is between 20 to 30 years and Gestational age before abortion less than 24 weeks.Female with unexplained two or three consecutive or discontinuous miscarriages with the same sexual partnerExclusion Criteria:Female with one miscarriageFemale with explained causes of miscarriageFemale with cancerFemale with chronic illness.Pregnant women above 30