A Study to Test How Different Doses of BI 765423 Are Taken up in the Body of Healthy Men

The main objectives of this trial are to investigate safety, tolerability and pharmacokinetics (PK) of BI 765423 in healthy male subjects following intravenous administration of single rising doses.

Inclusion Criteria:Healthy male subjects according to the assessment of the investigator, as based on a complete medical history including a physical examination, vital signs (blood pressure (BP), pulse rate (PR)), 12-lead Electrocardiogram (ECG), and clinical laboratory testsAge of 18 to 55 years (inclusive)Body mass index (BMI) of 18.5 to 29.9 kg/m2 (inclusive)Signed and dated written informed consent in accordance with International Council for Harmonisation-Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trialMale subjects who are willing to use condoms to prevent unintended exposure of their partner (both, male and female) from time point of administration of trial medication until completion of the trial. Male subjects with female partners must meet one of the following criteria for a highly effective contraception from at least screening until at least 90 days after drug administration:Use of combined (estrogen and progestogen containing) hormonal contraception that prevents ovulation (oral, intravaginal or transdermal) by female Women of child-bearing potential (WOCBP) partner, plus condom in male subjectUse of progestogen-only hormonal contraception that inhibits ovulation (only injectables or implants) by female WOCBP partner, plus condom in male subjectUse of intrauterine device (IUD) or intrauterine hormone-releasing system (IUS) by female WOCBP partner, plus condom in male subjectMale subject is vasectomised (vasectomy at least 1 year prior to enrolment) and received medical assessment of the surgical success (documented absence of sperm), plus condom in male subjectFemale partner is surgically sterilised (including hysterectomy), plus condom in male subjectFemale partner is postmenopausal, defined as no menses for at least 1 year without an alternative medical cause, plus condom in male subject Alternatively, true abstinence is acceptable, if it is in line with the subject's preferred and usual lifestyle. If a subject is usually not sexually active, but becomes active with their partner, they must comply with the contraceptive requirements detailed above.Exclusion Criteria:Any finding in the medical examination (including BP, PR or ECG) deviating from normal and assessed as clinically relevant by the investigatorRepeated measurement of systolic blood pressure outside the range of 90 to 140 millimetre of mercury (mmHg), diastolic blood pressure outside the range of 50 to 90 mmHg, or pulse rate outside the range of 45 to 90 beats per minute (bpm) (subjects with heart rate values between 45 and 50 bpm may be enrolled in case they have a normal thyroid function, no clinical symptoms associated with the bradycardia and no apparent signs of other diseases causing bradycardia such as hypothyroidism)Any laboratory value outside the reference range that the investigator considers to be of clinical relevanceAny evidence of a concomitant disease assessed as clinically relevant by the investigatorGastrointestinal, hepatic, renal, respiratory, cardiovascular, metabolic, immunological or hormonal disordersMajor surgery (major according to the investigator's assessment) performed within 3 months prior to screening or planned after screening during the study, e.g. hip replacementDiseases of the central nervous system (including but not limited to any kind of seizures or stroke), and other relevant neurological or psychiatric disordersHistory of relevant orthostatic hypotension, fainting spells, or blackouts Further exclusion criteria apply. Further exclusion criteria apply.