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Completed
NCT05656989
GCF PLAP-1, Sclerostin and TNF-α Levels in Periodontitis
Conditions: Periodontitis
Sex: All
Ages: 27 Years – 46 Years
Healthy volunteers: 1
Enrollment: 71
Sponsor: Aydin Adnan Menderes University
Location: Turkey
Summary
Periodontal ligament-associated protein-1 (PLAP-1) and sclerostin play an important role in the suppression of bone formation.
Tumor necrosis factor-alpha (TNF-α) is an important proinflammatory cytokine involved in periodontal bone loss.
This study aims to investigate gingival crevicular fluid (GCF) PLAP-1, sclerostin and TNF-α levels in individuals with periodontal disease.
Totally 71 systemically healthy and non-smoker individuals consisting of stage 3 grade C periodontitis (n=23), gingivitis (n=24) and periodontally healthy (n=24) were enrolled.
Periodontal status was evaluated by measuring the full-mouth clinical periodontal parameters.
GCF PLAP-1, sclerostin and TNF-α total amounts were measured by ELISA.
Data were analyzed using non-parametric statistical tests.
Eligibility Criteria
Inclusion Criteria:no history of smoking (determined by self-reporting)had a minimum of 18 natural remaining teeth (excluding third molars).Exclusion Criteria:suffered from diabetes mellitus, rheumatoid arthritis, cardiovascular and respiratory system diseases, hepatic and renal failure, metabolic bone diseases, endocrine disorders, immunologic and mucocutaneous diseasesused immunosuppressive agents, antibiotics, anti-inflammatory and anti-resorptive drugs, topical antiseptic solutions, calcium channel blockers, beta-blockers, anticoagulants and hormonal contraceptives within the past 3 monthspregnant or lactatingreceived any periodontal intervention in the past yearused removable partial dentures or orthodontic appliances
Source: ClinicalTrials.gov (NCT05656989). StuddyBuddy aggregates publicly available trial information.
