Udall Project 2 Aim 2A&C

This protocol will leverage the novel (on-label, FDA-approved) local field potential measuring capability of the Medtronic Percept™ PC DBS system to study the effects of globus pallidus internus and globus pallidus externus (GPi, GPe) DBS on: the wash-out and wash-in dynamics of motor behavior and local field potentials (LFPs) and correlations between fluctuations in gait and LFPs during activities of daily living (recorded over 4 weeks). These experiments will elucidate the relationships between GP LFPs oscillations, lower limb function, postural control and gait performance.

Inclusion Criteria:Receiving DBS therapy in GP for treatment of PDImplanted with Medtronic Percept DBS systemAt least 3 months since initial activation of the neurostimulatorExclusion Criteria:history of musculoskeletal disorders that significantly affects the ability to perform the motor tasks in the specific experiment in questionhistory of dementia or cognitive impairmentother significant neurological disorder as determined by the PIpost-operative complications or adverse effects (e.g. ON stimulation dystonias) that affect patient safety or confound the experimentlack of capacity to consent (as identified by UBACC)