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Completed
NCT05656391
Impact of Bread Diet on Intestinal Dysbiosis and Irritable Bowel Syndrome Symptoms in Quiescent Ulcerative Colitis
Conditions: Ulcerative Colitis in Remission
Sex: All
Ages: 18 Years – N/A
Phase: NA
Enrollment: 31
Sponsor: Institut d'Investigació Biomèdica de Girona Dr. Josep Trueta
Location: Spain
Summary
The present study aimed to compare the in vivo prebiotic properties of bread produced by traditional breadmaking techniques with that made using a modern breadmaking method on Irritable Bowel Syndrome-like symptoms in patients with quiescent Ulcerative Colitis.
The expected outcome of the differential effects was a change in the faecal microbiome composition, which may indicate changes in the mucosa-associated microbiota.
Eligibility Criteria
Inclusion Criteria:Patients diagnosed with ulcerative colitis according to established clinical and histological criteria as common clinical practiceRemission of ulcerative colitis defined as a total Mayo score ≤2 and faecal calprotectin values under 250 ng/gSubjects aged over 18 yearsModerate-to-severe IBS-like symptomatology defined by Rome IV criteria and IBS Symptom Severity Score (IBS-SSS) > 175.Exclusion Criteria:Presence of flare-up of UCCoeliac disease, colectomy, or intestinal resectionAntibiotic intake, prebiotic or probiotic treatment within 3 months before the studyAny malignancy, pregnancy, or breastfeedingIntake of medication potentially influencing gastrointestinal functionDisability to give informed consent
Source: ClinicalTrials.gov (NCT05656391). StuddyBuddy aggregates publicly available trial information.
