Porphyromonas Gingivalis and Severity of Fibrosis in Patients With Non-alcoholic Fatty Liver Disease

Many studies suggest that Porphyromonas gingivalis, a virulent periodontopathogenic bacterium, is associated with many systemic diseases such as cardiovascular diseases. In addition, a recent study showed the impact of Porphyromonas gingivalis on Non-Alcoholic Steatosis Liver Disease (NASH). It would be responsible for aggravation of non-alcoholic fatty liver disease (NAFLD) by stimulating inflammation in the damaged liver tissue.

Inclusion Criteria:subjects with NAFLD confirmed by a biopsy less than 1 year oldsubjects over the age of 18subjects able to receive information on the course of the study and to understand the information form to participate in the studythe subjects who gave their non-objection to participate in the studyExclusion Criteria:Having another associated cause of liver disease or steatosis such as viral infections and autoimmune diseaseWith alcohol consumption >30g/d (men) or 20g/d (women)With a history of cirrhosis decompensationHaving taken antibiotics, prebiotics or probiotics in the month prior to inclusionWith chronic or acute gastrointestinal diseaseWith a history of gastrointestinal surgery modifying the anatomyDuring pregnancy or breastfeedingWith a history of oral surgery in the month prior to inclusionFor whom oral surgery is planned between the collection of the non-objection and the inclusion in the odontology serviceAt risk of infection (existence of one or more known chronic infectious pathologies) and/or chronic renal failure (creatinine clearance < 60ml/min).Suffering from a general pathology contraindicating the performance of diagnostic procedures such as periodontal probing (patients at high risk of infective endocarditis according to the French National Agency for the Safety of Medicines and Health Products ANSM)Under legal protection, dependent, under guardianship or curatorship