Efficacy and Safety of Shen Que (RN8) Moxibustion in Unexpected POR

Moxibustion of Shen Que (RN8) can increase the number of embryos available for transfer, thus improving pregnancy outcomes in women of advanced reproductive age who experience unexpected poor ovarian response.

Inclusion Criteria:≥35 years old with normal pre-stimulation ovarian reserve parameters (antral follicle count (AFC) ≥ 5 or anti-mullerian hormone (AMH) ≥1.2 ng/ml) and with an expected poor ovarian response (fewer than 4 oocytes) after standard ovarian stimulation.Exclusion Criteria:Individuals with a Body Mass Index (BMI) ≥ 35 Kg/m2Those using the natural cycle or mild stimulation for IVF/intracytoplasmic sperm injection (ICSI) treatmentThose with a history of unilateral oophorectomy or recurrent pregnancy loss, defined as two or more spontaneous abortionsAcceptors of donated oocytes or performed either In vitro Maturation (IVM) or blastocyst biopsy for Preimplantation Genetic Diagnosis (PGD) or Preimplantation Genetic Testing for Aneuploidies (PGT-A)Those previously diagnosed with congenital (e.g., mediastinal uterus and double uterus) or acquired (e.g., submucosal myoma and adenomyosis) uterine abnormalitiesPatients with extremely advanced age ( ≥ 45 years old)Presence of a non-surgically treated hydrosalpinx or endometrial polyp and an ovarian endometriosis cyst requiring surgery, during ovarian stimulation