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Completed
NCT05653245
The Use of Adhesion Molecule Loaded Hydrogel With Minimally Invasive Surgical Technique in Treatment of Periodontal Intrabony Defect
Conditions: Periodontitis
Sex: All
Ages: 20 Years – 55 Years
Healthy volunteers: 1
Phase: PHASE1, PHASE2
Enrollment: 45
Sponsor: Minia University
Location: Egypt
Summary
Primary aim of the study is to evaluate efficacy of RGD adhesion molecule loaded hydrogel with minimally invasive surgical technique in treatment of periodontal intrabony defect at baseline and 6months.
Secondary outcome is the biochemical evaluation to detect bone morphogenetic proteins level
Eligibility Criteria
Inclusion Criteria:- Patients with diagnosis of periodontitis (stage III or IV and grade B or C) according to new American Academy of Periodontology classification (Tonetti et al., 2018a) (Nguyen et al., 2021).Selected patients of both sexes were 20-55 years old.All single and multiple rooted teeth in both maxilla and mandible.Presence of interdental periodontal pocket with intrabony defect.Patients were free from any systemic diseases that could alter their periodontal status, complicate the surgical treatment, or affect healing according to Modified Cornell Index (Abramson, 1966).No antibiotics or any medications that affect bone or soft tissue condition were taken during the last six months.Exclusion Criteria:Patients who received regenerative periodontal therapy last 6 months before the initial examination.Pregnant or lactating females.Smokers were not included as participants in this study.Patients not committed to oral hygiene after the re-evaluation of phase I therapy.Teeth with mobility more than Grade I.Third molars.
Source: ClinicalTrials.gov (NCT05653245). StuddyBuddy aggregates publicly available trial information.
