INhaled Salbutamol vs Placebo for the Treatment of Acute IgE-mediated Abdominal Pain From Allergic Food REactions

The goal of this study is to assess the efficacy of inhaled salbutamol to treat abdominal pain during food allergic reactions.Patients experiencing abominal pain as a result of a food allergic reaction during a food challenge in the allergy clinic will be invited to participate to the study.They will receive either 8 puffs of salbutamol (asthma inhaler) or 8 puffs of a placebo inhaler.The abdominal pain will then be followed using a numeric scale to see if patients receiving the medication experienced a faster improvement compared to those receiving the placebo.

Inclusion Criteria:Subjects aged between 6 to 55 years old.Undergoing an oral food challenge or an oral immunotherapy up-dosing visit for the diagnosis or treatment of an IgE-mediated food allergy.Previous confirmation of the food allergy by either skin prick tests (SPT) or serum specific IgE;Able to express the intensity of their pain using the NRS-11;Willing to comply with all study requirements.Exclusion Criteria:Previous adverse reactions to salbutamol;Known hypersensitivity to salbutamol or placebo or any of their components;Any condition that could be considered a relative contra-indication to the use of salbutamol according to the investigator (e.g. patient with a history of hyperglycemia, arrhythmia or hypokalemia);Patients receiving beta-blockers or a daily / long-acting beta agonists;Patients needing to pass an anti-doping test for high-level sport in the following 24h.