Neuroprotective Effects of ACTH4-10PRO8-GLY9-PRO10 | Clinical Trial | StuddyBuddy@endsection Neuroprotective Effects of ACTH4-10PRO8-GLY9-PRO10
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Completed NCT05648526

Neuroprotective Effects of ACTH4-10PRO8-GLY9-PRO10

Conditions: Ketamine-Induced Neurotoxicity

Sex: Male
Ages: 7 Days – 7 Days
Phase: NA
Enrollment: 42
Sponsor: Universitas Sumatera Utara

Location: Indonesia

Summary

The compound ACTH4-10Pro8-Gly9-Pro10 is a synthetic analog molecule of an adrenocorticotropic hormone (ACTH) short fragment. That is free from hormonal effects and has neuromodulatory effects. We investigate the neuroprotective effects of ACTH4-10Pro8-Gly9-Pro10 can lessen neurotoxicity against ketamine in neonatal rats by looking at BDNF expression in the cortex and hippocampus tissue as well as BDNF blood levels.

Eligibility Criteria

Inclusion Criteria:Rattus norvegicus ratsMale, seven days old, weighing 15-20 gramsSpraque-Dawley strain, obtained from the Experimental Animal Care UnitExclusion Criteria:Animals that behave aggressively in observation by attacking other groups

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05648526). StuddyBuddy aggregates publicly available trial information.