Association of Asprosin in Periodontitis and Acute Coronary Syndrome

Asprosin, a recently discovered glucogenic adipokine, is mainly synthesized by white adipose tissue and released during fasting. Appetite, glucose metabolism, insulin resistance, cell apoptosis, etc. asprosin is associated with diseases such as diabetes, obesity, polycystic ovary syndrome, and cardiovascular diseases. Periodontal tissue may act as a source of endocrine-like inflammatory mediators (such as TNF-α, IL-6 and IL-1) that are important in periodontal inflammation and can affect glucose and lipid metabolism. Production of TNF-α and IL-6 in adipose tissues strengthens the relationship between cardiovascular diseases and periodontitis. Investigators postulated that asprosin may be a candidate for explaining the triangular relationship between cardiovascular and periodontal disease.

Inclusion Criteria:For Healthy groupAll individuals were generally healthy,non-smoking For Myocard Infarctus grouppatients with ST elevation of Myocardial Infactuspatient with less than ten teethExclusion Criteria:Smokers or those with diabetes or other inflammatory diseasePregnant or breastfeeding womenNone had undergone periodontal therapy and/or antibiotic therapy in the past 6 months.None has a contagious disease such as HIV or AIDS