Inflammation, Platelets and Sickle Cell Disease

Sickle cell disease (SCD) is an autosomal recessive genetic disorder linked to a single mutation on beta-globin chains. This leads to red blood cell deformation and chronic hemolysis which can result in vaso-occlusive events, anemia and vasculopathy. Pathophysiology is incompletely understood, and beyond red blood cell's abnormalities this involves hemostasis and innate immunity. The aim of our study is to describe the mechanisms of thrombo-inflammation during the vaso-occlusive crisis (VOC) in adults with sickle cell disease.

Inclusion Criteria:Patient with sickle cell disease diagnosis, hospitalized in emergency department and/or internal medicine departmentPatient older than 18 yearsWritten consent to participate to the studyPatient with health insurancePatient able to receive information about the studyExclusion Criteria:Age < 18 yearsNon consent to participate to the studyWomen in pregnancy or breastfeedingTreatment with aspirin or non steroidal anti inflammatory drugProtected patientPatient already involved in a study requiring collection of additional biological samples