CAR-NK Targeted CD19 for r/r B-cell Malignancies

This is a single-centre, single-arm and open-label study to investigate the safety and efficacy of JD010 in adult patients with relapsed or refractory B cell hematologic malignancies. JD010 injection is a CD19-targeted chimeric antigen receptor modified natural killer cells (CAR-NK) derived from a healthy donor

Inclusion criteria:Age ≥ 18 years old, no gender or race;Expected survival period ≥ 3 months;Eastern Cooperative Oncology Group (ECOG) performance status score of 0 to 2;Confirmed relapsed/refractory B-cell malignancies and tumor cells expressing CD19;Adequate organ function:A. Liver function: ALT≤3×ULN, AST≤3×ULN, total bilirubin≤2×ULN; B. Coagulation function: international normalized ratio (INR) or activated partial thromboplastin time (APTT) ≤ 1.5×ULN; C. Renal function: serum creatinine≤1.5×ULN or creatinine clearance rate ≥30mL/min; D. Cardiac function: Left ventricular ejection fraction (LVEF) ≥ 50%;Women of child-bearing potential and all male participants must use effective methods of contraception for at least 12 months after infusion.;Informed Consent/Assent: All subjects must have the ability to understand and the willingness to sign a written informed consent.Exclusion Criteria:Central nervous system involved;Known contraindication to the protocol defined lymphodepleting chemotherapy regimen of fludarabine/cyclophosphamide;Systemic use of hormones within 4 weeks prior to enrollment (except for patients with inhaled corticosteroids);Any active infection requiring systemic therapy by intravenous infusion within 14 days prior to the first dose of study drug, including: HBV, HCV, HIV, syphilis infection, or active pulmonary tuberculosis.History of hypersensitivity reactions to murine protein-containing products, or macromolecular biopharmaceuticals such as antibodies or cytokines;Patients cannot guarantee effective contraception (condom or contraceptives, etc.) within 1 years after enrollment;Women who are pregnant (urine/blood pregnancy test positive) or lactating;Suffering from a serious autoimmune disease or immunodeficiency disease; 9 Suffering from mental illness;10. Known alcohol dependence or drug dependence; 11. According to the investigator's judgment, the patient has other unsuitable grouping conditions.