Neoadjuvant TIL- and Response-Adapted Chemoimmunotherapy for TNBC

This study will assess if the presence of immune system cells in and around the tumor impacts tumor shrinkage in patients receiving neoadjuvant chemoimmunotherapy for triple-negative breast cancer.

Inclusion Criteria:Ability of participant OR Legally Authorized Representative (LAR) to understand this study, and participant or LAR willingness to sign a written informed consentFemale subjects 18-70 years of ageHistologically confirmed cT1c-T3 cN0-N2 cM0 TNBCThe invasive tumor must be hormone receptor poor, defined as both estrogen receptor (ER) and progesterone receptor staining in ≤ 10% of invasive cancer cells by IHCThe invasive tumor must be HER2-negative based on the current ASCO-CAP guidelinesNo previous ipsilateral breast surgery for the current breast cancerNo previous chemotherapy, immunotherapy, endocrine therapy, or radiotherapy for the current breast cancerECOG Performance Status 0 - 1 documented within 10 days prior to the start of study treatmentBreast and axillary imaging (including ultrasound and MRI) within 30 days prior to treatment initiationSubjects with clinically and/or radiographically abnormal axillary or internal mammary lymph nodes should have pathologic confirmation of disease status with image-guided biopsy or fine needle aspirationHave provided archival breast tumor tissueStaging to rule out metastatic disease is suggested for patients with clinical TNM stage III diseaseSubjects with bilateral synchronous TNBC are eligible if they meet other eligibility criteriaNo baseline neuropathy greater than grade 2Patients are not pregnant, not breastfeeding, and either not a woman of childbearing potential or agrees to follow specific contraceptive guidelines during the treatment period and for at least 120 days after the last dose of study treatmentAdequate hematologic, hepatic, and renal function assessed ≤ 10 days from treatment initiationLVEF ≥ 50% by echocardiogram or MUGA scanExclusion Criteria:Current or anticipated use of other investigational agents while participating in this studySubject has previously received chemotherapy, immunotherapy, endocrine therapy, radiotherapy, or surgery for this breast cancerSubject has clinically or radiographically detected metastatic diseaseSubject has inflammatory breast cancerSubject has a concurrent or previous malignancy within the last five years (patients with squamous cell or basal cell carcinoma of the skin, ductal carcinoma in situ (DCIS) of the breast, or carcinoma in situ (CIS) of the uterine cervix who have undergone definitive therapy are not excluded from participation)History of allergic reactions attributed to doxorubicin, cyclophosphamide, carboplatin, or docetaxelHistory of severe (≥ grade 3) hypersensitivity to pembrolizumab or any of its excipientsPrior treatment with an anti-PD-1, anti-PD-L1, anti-PD-L2 inhibitor or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g., CTLA4, OX40, CD137)If participant has received major surgery, they must have recovered adequately from the toxicity and/or complications from the intervention prior to starting study treatment.Subject has received a live vaccine within 30 days prior to treatment initiationSubject is currently receiving treatment or has received treatment with an investigational agent within four weeks prior to treatment initiation, or has used an investigational device within four weeks prior to treatment initiationHas a diagnosis of immunodeficiency or is receiving chronic steroid therapy (in doses exceeding 10 mg daily prednisone equivalent) or any other form of immunosuppressive therapy within seven days prior to the first dose of pembrolizumabActive autoimmune disease that has required systemic treatment (e.g., disease-modifying agents, corticosteroids, immunosuppressive drugs) in the past two yearsCurrently has or has history of (within the past one year) non-infectious pneumonitis requiring steroidsActive infection requiring systemic therapyKnown history of human immunodeficiency virus (HIV) infectionActive hepatitis B (defined as HBsAg reactive) or hepatitis C (detectable HCV RNA)History or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of this study, interfere with the subject's participation for the full duration of the study, or it is not in the best interest of the subject to participate, in the opinion of the treating investigatorSubject has known psychiatric or substance abuse disorder(s) that would interfere with cooperation with the requirements of the studySubject is pregnant or breastfeeding or expecting to conceive within the projected duration of the study, starting with the screening visit through 120 days after the last dose of trial treatmentInadequate hematologic, renal, hepatic, or cardiac function.Myocardial infarction, unstable angina pectoris, an arterial thrombotic event, stroke, or transient ischemic attack within the past 12 months, uncontrolled hypertension (systolic BP > 160 mmHg, diastolic BP > 90 mmHg), uncontrolled or symptomatic arrythmia, or greater than grade 2 peripheral vascular disease