Direct Detection of ESKAPE Pathogens From Whole Blood Using T2MR Bacterial Panel in Patients With Pyogenic Spondylodiscitis and Infectious Endocarditis

Conditions: Vertebral Osteomyelitis, Infectious Endocarditis

Sex: All

Enrollment: 80

Sponsor: Charles University, Czech Republic

Location: Czechia

Summary

Our prospective observational study focuses on rapid diagnostics of 6 most frequent etiological agents of pyogenic spondylodiscitis and infectious endocarditis known under acronym ESKAPE (E. coli, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa and E. faecium) by T2 Biosystems Bacterial Panel. This diagnostic method combines PCR and T2 magnetic resonance for whole blood sample detection. Similar studies were performed in recent years using Candida Panel and Bacteria Panel evaluating diagnostics of BSI leaving us with optimistic results. This study aims to show that T2B is able to detect localized infections such as spondylodiscitis and endocarditis with higher sensitivity and specificity and with better time to result in comparison with BC. Rapid detection may improve the outcomes e.g. mortality and may shorten duration of treatment by early definitive antibiotic administaration.

Eligibility Criteria

Inclusion Criteria:Diagnosis of spondylodiscitis or/and infectious endocarditis.Exclusion Criteria:Etiology other than ESKAPE pathogens (ESKAPE (i.e. Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species).

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05644990). StuddyBuddy aggregates publicly available trial information.