Mitochondrial Function in Peripheral Arterial Disease

The aim of this study is to investigate the effect of different treatment strategies on mitochondrial function and to correlate in-vitro results to findings from in-vivo measurements of mitochondrial function. The authors hypothesize that interventional revascularization and therefore the restoration of blood and oxygen supply is more relevant to mitochondrial function compared to the effect of exercise training.

Inclusion Criteria:Isolated flow limiting arteriosclerotic lesion of the superficial femoral arteryUnilateral grade II b (Fontaine) peripheral arterial diseaseInformed consentExclusion Criteria:Flow limiting arteriosclerotic lesions of the infrarenal aorta, iliac arteries or common/ deep femoral arteryContraindication for exercise therapy