Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks

The purpose of this study is to use non-invasive brain imaging methods (MEG and EEG) to characterize the effects of THC on brain activity during learning.

Inclusion Criteria:Cannabis use at least once in the past 12 monthsNo cannabis use during the course of the study confirmed with negative urine toxicology at screening and on each test dayGood physical and mental healthExclusion Criteria:Cannabis naïve individualsLifetime or current medical, psychiatric or psychosocial disorders or history that is deemed unsuitable for participation in the study per PI discretion.Positive pregnancy test, lactation, or refusal to practice birth control for the duration of the study and for two weeks following completionMajor current or recent stressorsPositive urine drug testContraindication for Magnetic Resonance ImagingTreatment with psychotropic medication as per discretion of the PIIQ less than 80Diagnosis of major psychotic or manic disorder in first-degree relatives.