Evaluation of Intraoperative Dexmedetomidine Use in Patients Undergoing Surgical Aortic Valve Replacement

Sex: All

Ages: 18 Years – 85 Years

Phase: PHASE3

Enrollment: 60

Sponsor: University Hospital Dubrava

Summary

Aim of this randomized prospective study is to investigate the immunomodulatory effects of dexmedetomidine on outcomes in patients with isolated aortic stenosis after surgical aortic valve replacement.

Eligibility Criteria

Inclusion Criteria:isolated aortic stenosis adult patients with written consentExclusion Criteria:BMI >30kg/m21st, 2nd and 3rd degree AV blockbradycardia HR<50/min upon arrival to operating theatreneurological disorders (Parkinson's disease, Myasthenia gravis, multiple sclerosis, brain tumors in anamnesis)recent use of psychoactive drugsalcohol and illicit drug addictiondiabetes type I with complicationspatients who develop hypotension after initiation of dexmedetomidine infusion requiring vasoconstriction therapypatients receiving corticosteroids in perioperative periodpatients with known allergy to dexmedetomidine

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05641064). StuddyBuddy aggregates publicly available trial information.