Pre-demential Motoric Cognitive Risk Syndrome in Ageing Subjects

Conditions: Motoric Cognitive Risk Syndrome, Mild Cognitive Impairment, Alzheimer Disease, Dementia

Sex: All

Ages: 55 Years – 80 Years

Healthy volunteers: 1

Enrollment: 160

Sponsor: University Hospital, Caen

Location: France

Summary

The main aim of the study is to characterize and understand the pathological mechanisms underlying the motoric cognitive risk syndrome, which is a predictor of Alzheimer disease.

Eligibility Criteria

Inclusion criteria:Aged 55-75 yearsRight-handed as assessed by the Edinburgh InventoryHealth InsuranceAble to follow experimental instructionsConsentIndependent in daily life activities as assessed by Katz autonomy score, ADL and IADLInclusion criteria (MCR group specific)Reduced gait speed as assessed by the 4m or 10m walk test value compared to normative values (Bohannon & Williams Andrews, 2011)Subjective cognitive complaint as assessed by dedicated questionnaireSubnormal cognitive function as assessed by the Montreal Cognitive Assessment (MoCA) test with score > 23Inclusion criteria (Controls group specific)- Subnormal cognitive function as assessed by the Montreal Cognitive Assessment (MoCA) test with score > 23Exclusion criteria:Uncorrected visual or auditive deficits not allowing the realization of the experimentEvolutive disease (such as cancer)Active depressionNeurological or psychiatric antecedentNeuromuscular impairmentBMI < 35Counter-indication to MRI

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View on ClinicalTrials.gov

Source: ClinicalTrials.gov (NCT05640141). StuddyBuddy aggregates publicly available trial information.