SRMA of the Effect of Soy Milk vs Cow's Milk on Cardiometabolic Outcomes

Dairy consumption has shown associations with decreased incidence of cardiometabolic diseases. With the growing interest in plant-based eating, and the mounting evidence for the cardiovascular benefits of plant forward diets, national dietary guidelines have pivoted away from promoting exclusive daily dairy consumption. Soy milk, the most nutritionally comparable plant-based milk alternative to cow's milk, is a commonly consumed source of heart-healthy soy protein. Though the beneficial effect of soy protein on lipid markers is well established, the impact on other cardiometabolic outcomes is unclear. To address this question and better inform health claims and guideline development, the investigators will conduct a systematic review and meta-analysis of randomized controlled trials of the effect of soy protein as soy milk, in substitution for cow's milk, on various intermediate cardiometabolic mediators.

Inclusion Criteria:Randomized controlled trialsSoy milk interventionCow's milk comparatorIntervention duration ≥ 3 weeksData for at least 1 outcomeExclusion Criteria:Non-human studiesObservational studiesAcute single-bolus feeding studiesParticipants < 18 years of ageMultimodal interventionsLack of suitable comparatorIntervention duration < 3 weeksNo viable outcome data