Determination of the ED50 and ED95 of Prophylactic Norepinephrine Infusion for Preventing Post-induction Hypotension in Elderly Patients Undergoing Major Abdominal Surgery

Sex: All

Ages: 65 Years – 80 Years

Phase: NA

Enrollment: 40

Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Summary

The goal of this clinical trial is to determine the ED50 and ED95 of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients undergoing major abdominal surgery using up-and-down sequential method . The main question it aims to answer is:What is the effective concentration of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients.Participants will receive different concentrations of norepinephrine infusion at the beginning of anesthesia induction until 15 minutes after intubation.

Eligibility Criteria

Inclusion Criteria:aged 65 to 80 yearsUndergoing major abdominal surgeryAmerican Society of Anesthesiologists (ASA) physical status of I/II/IIIExclusion Criteria:Patient refusalSevere untreated or uncontrolled hypertension despite medicationsBradycardia (heart rate < 50 beat per minute)Cardiac morbidities, heart block greater than the first degreeSevere hepatic and renal dysfunctionhyperthyroidismvascular diseasesBMI>30Monoamine oxidase inhibitors were used 2 weeks before surgery

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Source: ClinicalTrials.gov (NCT05637164). StuddyBuddy aggregates publicly available trial information.