Plan of the Day Radiotherapy

The study objectives are to improve the treatment of LACC patients and to increase knowledge of the potential benefit of the plan-of-the-day concept on side effects during and after radiotherapy.

Inclusion Criteria:Histologically confirmed cervical cancer eligible for definitve radiochemotherapyFIGO stage IB1-IVaOver 18 yearsSpeaks and understands Norwegian or English.ECOG 0-2Histology: Squamous cell carcinoma, adenocarcinoma, adenosquamous carcinomaAbility to understand and fill in patient questionnaires, and willing to sign a written informed consentLarge movers (LM), fundus movement ≥2,5 cm.Exclusion Criteria:Evidence of distant metastasis. Suspicious paraaortic lymphnodes below the renal vessels is allowed if they are covered by the radiation fieldPatients with previous surgery for their cervical cancerUncontrolled intercurrent somatic illness.Psychiatric illness /social situations limiting study compliancePrior radiotherapy to the pelvisPatients who are pregnant or breastfeeding is excluded due to risk of teratogenic and abortifacient effects of radiotherapy and cisplatin, and the potential risk of adverse effect of nursing infantsPatients under current treatment for other invasive s except non-melanoma skin cancersNephrostomyPatients with inflammatory bowel disease