CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis.

Cardiac dysfunction is common following hospital admission with sepsis and one of the most frequent causes for readmissions to hospital, however underlying mechanisms by which this might occur are unclear. The CONDUCT-ICU investigators will conduct a pilot, cohort study, characterizing cardiac function in ICU survivors of sepsis using a combination of CMR imaging, biomarkers and patient reported outcome measures to investigate mechanisms of cardiac dysfunction following sepsis. Comparisons will be made to that of the general population.

Inclusion Criteria:Provision of informed consent.Age > 18 years.ICU admission with sepsis (According to The Third International Consensus Definitions for Sepsis and Septic Shock [Sepsis-3])17Ability to comply with study proceduresExclusion Criteria:Inability to give informed consentPregnancy.Ongoing participation in any investigational research that may undermine the scientific basis of the study.Contraindications to magnetic resonance imaging:i. Cardiac pacemaker, artificial heart valve, neurostimulator, cochlear implant ii. Aneurysm clips iii. Metal injuries to the eye iv. Loose metal in any part of the body v. Severe claustrophobiaKnown Coronary Artery DiseasePrevious Myocardial InfarctionChronic Heart Failure prior to ICU admissionPatient receiving immune modulating drug or biologic therapy either long term or during acute admissionPatient considered by the clinical team to be very unlikely to survive to hospital dischargeHospital Admission because of Covid-19Patients undergoing treatment for malignancy with systemic anti-cancer therapies.