Central Sensitization and Physical Activity in Adolescents With HSD/hEDS

Hypermobility Spectrum Disorder and hypermobile Ehlers-Danlos Syndrome (HSD/hEDS) is under-recognized and poorly understood and its management is therefore not clear.The goal of this study is to better understand pain and its impact on function in the daily activities of adolescents with Hypermobility Spectrum Disorder and/or hypermobile Ehlers-Danlos Syndrome.This study will explore the presence of the pain sensitivity status after physical exercise as well as movement behaviour in adolescents with HSD/hEDS compared to a healthy control group.

Inclusion criteria for the HSD/hEDS group:Able to read and understand SwedishDiagnosed with HSD or hEDSExclusion criteria for the HSD/hEDS group:Pregnancy and one year postpartum.Other syndromes with hypermobility such as the Marfan syndrome, Osteogenesis Imperfecta or other types of EDS.Co-morbidity with neurological disordersInclusion criteria for the control group:Able to read and understand SwedishHealthyPain free at time of investigation (Numerical Rating Scale score <3/10).Exclusion criteria for the control group:Pregnancy and one year postpartum.Past or present signs of rheumatic, neurologic, musculoskeletal, metabolic diseases.Chronic pain.