Minocycline Accelerates Intracerebral Hemorrhage Absorption

Minocycline has been found to reduce cerebral edema secondary to cerebral hemorrhage, promote hematoma absorption, and shorten hematoma absorption time; clinical studies have been conducted to confirm the safety in the treatment, but no significant hematoma absorption effect was seen with short duration of drug use. Therefore, the investigators propose to conduct a multicenter randomized controlled clinical trial to determine its accelerating effect on hematoma absorption.

Inclusion Criteria:18-80 years oldSpontaneous intracerebral hemorrhage by CT scanIntracerebral hematoma volume is less than 16mlNo surgical treatment of hematoma evacuationExclusion Criteria:Allergies to tetracycline antibioticsPregnancy or suspected pregnancy (pregnancy test will be done on women with fertility potential)Hepatic and/or renal insufficiencyGlasgow Coma Scale of 5 or lessSecondary cerebral hemorrhage caused by trauma, arteriovenous malformation, aneurysm, tumor or other reasonsThrombocytopenia (platelet count<75000/mm3) or coagulation dysfunction (INR>1.4)Incapable to take care of themselves in past life (score of Rankin scale before stroke>2)Signed DNR (Do Not Resuscitate)