Cancer Risk Assessment in Patients With a Constitutional Alteration of the PTEN Gene

This is a multicentric, observational, retrospective and prospective study, aiming to estimate the risk of cancer occurrence in subjects carrying a PTEN mutation, based on the constitution of a national cohort.

Inclusion Criteria:Male or female.Adult or child without age limit.Carrier of a constitutional alteration of the PTEN gene established and/or confirmed by the Institut Bergonié's genetics laboratory, following a request for molecular diagnosis made between 1997 and 2027.Participant informed of his genetic diagnosis.Participant informed and not having expressed non-opposition to participate in the research.Participant affiliated to a French social security system in accordance with French law on research involving the human person.Exclusion Criteria:Participant under guardianship or curatorship.Persons deprived of their liberty by a judicial or administrative decision, persons under psychiatric care, persons admitted to a health or social institution for purposes other than research.