This is a Single Arm, Open Label Trial With Iptacopan Treatment for 24 Weeks, in Patients on Stable Regimen of Anti-C5 Who Switch to Iptacopan.

The purpose of the study is to find out if iptacopan is effective and safe in adult patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) who switch from their current standard of care treatment (eculizumab or ravulizumab) to study treatment, iptacopan/LNP023.

Inclusion Criteria:Signed informed consent must be obtained prior to participation in the study.Male and female participants ≥ 18 years of age, at the time of ICF signatures and with a diagnosis of PNH confirmed by treating physician.Stable regimen (dose and intervals) of anti-C5 antibody treatment (either eculizumab or ravulizumab) for at least 6 months prior to screeningMean hemoglobin level ≥10 g/dLVaccination against Neisseria meningitidis and S. pneumoniae infection are required prior to the start of iptacopan treatment.If not received previously, vaccination against Haemophilus influenzae infections is recommended, if available and according to local regulations.Ability to communicate well with the investigator, to understand and comply with the requirements of the studyOther protocol -defined inclusion criteria may apply at the end.Exclusion Criteria:Participation in any other investigational drug trial or use of other investigational drugs at the time of enrollmentPatients requiring red blood cell transfusion in the 6 months prior to screening or during screeningHistory of stem cell transplantation or any solid organ transplantationActive systemic bacterial, viral (incl. COVID-19) or fungal infection within 14 days prior to study drug administrationPresence of fever ≥ 38.0 °C (100.4 °F) within 7 days prior to study drug administrationHuman immunodeficiency virus (HIV) infection (known history of HIV or test positive for HIV antibody at Screening)A history of recurrent invasive infections caused by encapsulated organisms, e.g. meningococcus or pneumococcusUnstable medical condition including, but not limited to, myocardial ischemia, active gastrointestinal bleeding, coexisting chronic anemia unrelated to PNH, or unstable thrombotic event not amenable to active treatment as judged by the investigator at Screening.History of cancer of any part of the body within the past 5 years,Ongoing drug or alcohol abuse that could interfere with patient's participation in the trial.Any medical condition deemed likely to interfere with the patient's participation in the studyFemale patients who are pregnant or breastfeeding, or intending to conceive during the course of the study