Effect of Early Non-invasive Phrenic Nerve Stimulation on Weaning in Mechanically Ventilated Patients

the early application of non-invasive PNS in MV patients can increase the number of days without mechanical ventilation, delay disuse phrenic atrophy, and improve the strength of inspiratory muscle.

Inclusion Criteria:Age ≥18years and ≤80years;MV time ≤48h;MV duration is expected to be ≥72h;The sternocleidomastoid region and pectoralis major region were completely exposed.Patients or family members are willing to sign informed consent and participate in the study.Exclusion Criteria:There are contraindications to PNS in vitro (Pneumothorax, active tuberculosis, pleural adhesions, installation of pacemakers and defibrillators, etc.);Neuromuscular disease (myasthenia gravis, etc.) or known anatomical abnormalities of the diaphragm;ECMO status;Hemodynamic instability;Uncorrected arrhythmias;Be pregnant;Clinical end-stage and palliative care patients.