Thiol/Disulphide Homeostasis in Unexplained Infertility

The aim in this study is to determine whether there is a relationship between Thiol / Disulphide levels in primary infertile patients and comparing them with infertile patients and the control group. For this purpose, 41 women followed up with the diagnosis of primary infertility in Siirt Training and Research Hospital between November 2022 and January 2023 will be included in the study. The same number of (n:41) non-infertile control women will be included. Age, pregnancy history and medical history of both groups will be recorded. FSH, LH, E2, TSH, and prolactin levels taken routinely in these patients will be examined. Thiol/disulphide levels in the blood will be checked by taking whole blood from these patients. In the light of the information thus obtained, the investigator plan to determine whether there is a relationship between oxidant/antioxidant balance in primary infertile patients.

Inclusion Criteria:Patients diagnosed with primary infertilityPatients between the age of 18-35Exclusion Criteria:Active hypertensionChronic liver or kidney failure historyCoronary artery diseaseAcute infection (within 14 days)Any chronic inflammatory diseasePresence of autoimmune diseaseKnown malignancyInflammatory bowel diseaseHormonal contraceptionSmokingalcohol useDrug usePatients with tubal infertilityPartner with abnormal spermiogram