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Completed
NCT05628753
Lung Ultrasound as a Predictor for Successful Extubation in Preterm Infants
Conditions: no Conditions
Sex: All
Enrollment: 20
Sponsor: Royal University Hospital, Saskatoon
Location: Canada
Summary
unit (NICU); however prolonged MV is known to be associated with serious complications including ventilator associated pneumonia, blood stream infections, bronchopulmonary dysplasia (BPD) and periventricular leukomalacia.
At the same time, extubation failure increases morbidities and mortality.
Hatch et al (2016) in their prospective study on 162 infants described adverse events in 40% of intubations and severe complications including need for CPR in 9%.
Reintubations are frequently associated with hypoxemia, bradycardia, fluctuations in blood pressures and cerebral perfusion.
Each intubation attempt increases the risk of traumatic injury to the upper airway, lung atelectasis and infections.
Thus, there is a clear need to establish objective criteria that would help avoid extubation failure and the need for reintubation.In recent years, a new imaging application has been introduced in neonatal practice-lung ultrasound (LUS), an accurate and reliable technique for the lung evaluation.
LUS is safe, non-ionizing, easy to operate, and low-cost tool.
The evaluation of lungs is performed in real-time, on the bedside and without anesthetic drugs.
Lung aeration could be assessed in dynamics without extra radiation to the infant.
Ultrasound findings combined with clinical information could be used for the prognosis of successful extubation in premature infants.
Eligibility Criteria
Inclusion Criteria:Invasively ventilated infants born at less than 32 weeks of gestational age were included at the time of their first extubationExclusion Criteria:infants born after 32 weeks of gestational age
Source: ClinicalTrials.gov (NCT05628753). StuddyBuddy aggregates publicly available trial information.