Real-time Computer Aided Detection of Barrett's Neoplasia

In the real-time pilot study, the performance of a recently developed Computer Aided Detection (CADe) system will be investigated in 30 patients during real-time live endoscopic examination. Three expert endoscopists in the field of Barrett's esophagus and endoscopic resection techniques will perform the inclusions following a standardized data acquisition protocol. In total, 15 patients with a visible neoplastic lesion in their Barrett's esophagus and 15 patients without any visible abnormalities in their Barrett's esophagus will be included in this study. Outcomes: to investigate feasibility of the use of the CADe system in the endoscopy suite, to investigate the performance of the CADe system when used by endoscopists.

Inclusion Criteria:Age > 18 years;Patients under surveillance for their diagnosed non-dysplastic Barrett's esophagus or patients refered for endoscopic treatment because of proven high-grade dysplasia or adenocarcinoma;A circumferential Barrett length of at least 2cmExclusion Criteria:Medical history of prior surgical or endoscopical treatment for neoplasia in their esophagusReflux esophagitis > grade 2 (LA classification)Inability to undergo endoscopic treatment and/or biopsies