Timing of Preload Responsiveness in Sepsis

During acute circulatory failure, volume expansion does not always lead to a significant increase in cardiac output (fluid responsiveness). After initial resuscitation by rapid fluid administration, cardiac preload is no longer extremely low and only half of the patients respond to further volume expansion with the expected increase in cardiac output (fluid unresponsiveness). However, the time delay or the volume of fluid needed to be administered from the state of fluid responsiveness to fluid unresponsiveness is still not determined.Objective To determine, in critically ill patients with acute circulatory failure,: the time and/or the volume of fluid needed from the state of fluid responsiveness to fluid unresponsiveness during septic shock.: determine the factors that influence this time and volume.

Inclusion Criteria:Age ≥ 18 ansOnset of septic shockExclusion Criteria:Planned to transfer the patient to another healthcare facility (inability to continue cardiac output measurements); urgent operation; Inability to measure the cardiac output.