COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA

The goal of this clinical trial is to compare different combinations of diclofenac with diclofenac monotherapy in acute sciatica. The main questions it aims to answer are:Does the combination of diclofenac plus codeine better than diclofenac monotherapy for treating severe pain of sciaticaDoes the combination of diclofenac plus lacosamide better than diclofenac monotherapy for treating severe pain of sciaticaParticipants will be asked to mark their pain intensity on a visual analog scale and fill oswestry disabilit index questionnaire,treatments they'll be given includes eitherDiclofenac monotherapyDiclofenac plus codeineDiclofenac plus lacosamideResearchers will compare the above three groups to see if severity of pain and disability lowered after medication

Inclusion Criteria:Patients diagnosed with acute sciatica with or without lower back pain18-70 years of age reporting acute pain due to sciaticaExclusion Criteria:Pregnant or breastfeeding mothers.History of asthma or allergy to anti-inflammatory drugs.Mentally handicapped or terminally ill patients.Age less than 18 years or above 70 yearsPatients with herniated, sequestrated, or prolapsed discs waiting for surgery.Patient having an active ulcer (gastric or duodenal) or bleeding from the stomach or bowel.Patients already taking an anti-depressant medication, a medication for neuropathic pain, an anticonvulsant, or a sedative and unable to cease the medication