Prospective Study of Short Course Radiation Therapy Followed by Neoadjuvant Chemotherapy and Surgery in Locally Advanced Rectal Cancer

The goal of this clinical trial is to investigate total neoadjuvant therapy (TNT) using short course radiation therapy (SCRT) followed by full course of chemotherapy then surgery in locally advanced rectal cancer. The main questions it aims to answer are:Is total neoadjuvant treatment in this design safe & tolerable?Impact of this design on treatment related outcomes in terms of pathological and clinical responses.

Inclusion Criteria:Histopathological proof of rectal adenocarcinoma.Tumors located within 15 cm and not less than 4 cm from anal verge.Age: ≥ 18 years.Locally advanced resectable rectal cancer (cT3/4 N0- Any T N+ve).ECOG Performance Status: 0-2.Exclusion Criteria:Non-epithelial rectal malignancy such as sarcoma or lymphoma.Unresectable tumors in which surgery will never be possible even if substantial tumor downsizing is seen.Recurrent rectal cancer.Previous history of malignancy within the last 5 years.Previous pelvic irradiation.Psychiatric or addictive disorder that would preclude study therapy.Concurrent uncontrolled medical conditions.Pregnancy or breast feeding.Any contraindication to surgery.Extensive peripheral neuropathy.