The Effects of Different Exercise Modalities in Adolescents With Type 1 Diabetes Using AID Systems

Objective:The overall objective of this study is to assess the efficacy of the current recommended guidelines for physical activity (PA) in response to acute moderate intensity continous exercise (MICE) and high intensity interval exercise (HIIE) among adolescents with type 1 diabetes (T1D) using automated insulin delivery (AID) systems (MiniMed 780G and Tandem Control-IQ).Methods:This study will be a two-period, cross-over, clinical trial with between and within cohort comparisons of two different exercise modalities among a total of 24 age-, sex-, and insulin-dose-matched adolescents with T1D (12 using MiniMed 780G and 12 using Tandem Control-IQ).Endpoint:The primary endpoint is sensor-derived time in range (3.9 mmol/L-10.0 mmol/L) around exercise

Inclusion Criteria:Age 13-17 years oldType 1 diabetes > 1 yearUse of Tandem t:slim X2 Control-IQ or Medtronic MiniMed 780G with connected continous glucose monitor > 3 monthsHbA1c below 75 mmol/LExclusion Criteria:Use of anti-diabetic medicine other than insulinBreastfeeding, pregnancy or planning to become pregnantLack of compliance with key study procedures at the discretion of the investigator