Effects of Acute and Chronic Exercise on Myeloid-Derived Suppressor Cells in Melanoma Patients

This study is designed to investigate the effects of ketogenic milieu induced by acute exercise as well as the effects of recurrent exercise bouts on functional status and the accumulation in peripheral blood of MDSCs and the consequent balance on antitumor immunity in melanoma patients.

Inclusion Criteria:Age from 18 to 65 years at the time of recruitmentHistologically confirmed diagnosis of primary melanomaPatients who are candidate to curative surgery for primary melanoma, skin radicalization or sentinel node biopsy.American Society of Anaesthesiologists (ASA) status IWillingness and ability to comply with the protocol, the scheduled visits, treatment plans, laboratory tests and other procedures.Understanding and signature of the informed consentFemale patients of childbearing potential must agree to sexual abstinence or to use highly effective method of contraception throughout the study (for CEP patients)Exclusion Criteria:American Society of Anaesthesiologists (ASA) status > IPregnancy or lactationKnown infection from HIV virusRegular physical exercise (more than 1 exercise workout of moderate to intense exercise activity per week)Any physical or mental conditions interfering with the ability to perform exercise or to complete the testing procedures.