Furosemide Stress Test to Predict Successful Liberation From RRT

The proposed study will evaluate if a standardised dose of furosemide administered in the 12 hours after RRT liberation can predict successful liberation in critically ill patients. The dose that will be administered is in accordance with the prescribing information.

Inclusion Criteria:Receiving continuous RRT for AKIHaving an indwelling urinary catheterClinical decision by physician in charge to attempt RRT liberation (first attempt)lnformed consent signed by the patient himself / legal representative or authorization received from independent physicianExclusion Criteria:Electrolyte disturbances or hemodynamic instability precluding the use of furosemide (sodium > 155 mmol/L and/or potassium < 3.0 mmol/L and/or metabolic alkalosis > 7.50 and/or mean arterial pressure < 60 mmHg)Furosemide allergyUrine output ≥ 100 mL/h for at least two hoursPrior FST during the ICU stayKnown end-stage chronic renal disease at ICU admissionWithdrawal of life support decision taken before inclusionPatient already participating in conflicting research study