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NCT05612399
Precision Analgesia for Cardiac Surgery
Conditions: Analgesia, Cardiac Surgery
Sex: All
Ages: 60 Years – 110 Years
Enrollment: 400
Sponsor: Kathirvel Subramaniam
Location: United States
Summary
The proposed research is an important extension of an ongoing perioperative personalized analgesia and intravenous opioid pharmacogenetic research.
This research focuses on two of the most commonly used oral opioid analgesics, oxycodone, and methadone in elderly adults undergoing cardiac surgery.
Eligibility Criteria
Inclusion Criteria:Elderly cardiac surgical patients over 60 years of ageExclusion Criteria:Methadone allergyMorbid obesity (BMI >40kg/cm2)Severe sleep apneaSevere pulmonary disease requiring oxygen therapyPreoperative mechanical circulatory supportEmergency surgeryLiver disease (liver enzymes more than two times normal)End-stage renal disease requiring dialysisSerum creatinine more than 2.0mg
Source: ClinicalTrials.gov (NCT05612399). StuddyBuddy aggregates publicly available trial information.
