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NCT05611307
Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors
Conditions: Testicular Cancer, Survivorship, ASCVD, Coronary Artery Disease, Lipid Disorder, Hypogonadism, Male, Cisplatin Adverse Reaction, Bone Marrow Transplant Complications
Sex: Male
Ages: 18 Years – 99 Years
Enrollment: 150
Sponsor: Indiana University
Location: United States
Summary
Late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant
Eligibility Criteria
Inclusion CriteriaPatients >18 years of agePatients will be recruited only if cancer-free at clinical evaluation time.For the cases a confirmed TC diagnosis who received one or more cycles of CBCT-based chemotherapies (CBCT group, Arm 2)For the cases with a confirmed TC diagnosis who received one or more cycles of CBCT-based chemotherapies and underwent BMT for relapsed refractory disease (CBCT & BMT group, Arm 3).For the comparison cohort, biopsy-proven TC patients who had surgery for or surveillance of their testicular cancer and never received CBCTCBCT or BMT (surgical/surveillance, Arm 1)Exclusion CriteriaPrior known myocardial infarction (MI), atherosclerotic cardiovascular disease (ASCVD)Significant renal disease (GFR<40)Allergy to iodinated contrastAntecedent chemotherapy for another primary cancer.
Source: ClinicalTrials.gov (NCT05611307). StuddyBuddy aggregates publicly available trial information.
