Effect of Injectable Platelet-rich Fibrin on the En Masse Retraction of Maxillary Anterior Teeth

The aim of this study is to investigate the effect of local injection of injectable platelet rich fibrin (i-PRF) on the rate of orthodontic en masse retraction of anterior teeth clinically and to report any associated pain as well.

Inclusion Criteria:Orthodontic patients with and age range (16 - 30) years.Protruded upper anterior teeth requiring extraction of first premolars and anterior teeth retraction; Angle class I mal-occlusion with bi-alveolar dental protrusions or class II division 1.Patients with full permanent dentition (with the exception of third molars).Healthy dental and periodontal condition with good oral hygieneExclusion Criteria:Patients with extensive restorations on the anterior teeth.Subjects taking medication affecting inflammatory process of the orthodontic tissue reaction.History of previous orthodontic treatment or trauma to the anterior teeth.Syndromic patients and patients with systemic diseases.Poor oral hygiene or periodontal diseases.