Comparison of Preserved and Preservative-free Latanoprost 0.005% in Primary Open Angle Glaucoma and Ocular Hypertensive Patients, at Guinness Eye Centre, Lagos.

It is a randomised, double-blinded clinical trial in which consenting participants who meet the inclusion criteria would be randomised into 2 groups. Subjects will be given either preserved or preservative free latanoprost for a period of 12 weeks. The efficacy and tolerability of both drugs would be assessed every 4 weeks, amongst these patients.

Inclusion Criteria:Recently diagnosed, consenting high tension, primary open angle glaucoma or ocular hypertensive patients.Forty years and above.Intraocular pressure of 21- 30mmHg (millimetres of mercury)Willingness to participate in the study.Exclusion Criteria:Patients under 40 years of age.Diabetic patientsPatients on other anti- glaucoma medications.Patients on topical immunosuppressive medication.Patients on anti-depressants.Patients who have had any form of ocular surgery or intervention such as cryotherapy.Patients using contact lens.Patients on any form of topical medication in the last 1 month.Patients diagnosed or suspected to have Sjogren syndrome.Patients being managed for Steven-Johnson's syndrome, ocular cicatricial pemphigoid.Pregnant patients.Previous glaucoma surgery and any refractive surgery <12 month prior to enrolment.Only eye patients.