The Effect of an Acute Bout of Exercise on Pain Sensitivity and Clinical Pain in Adults With Knee Osteoarthritis

The goal of this interventional study is to investigate the effectiveness of an acute bout of exercises on pain sensitivity and clinical pain among adults with knee osteoarthritis. The following question will be answered in this research Q1: Is acute bout of exercise effective in reducing pain among adult with knee osteoarthritis?Participants who agree to participate and sign the informed consent will be randomised to one of three groups:Group 1: Isometric exercise with neutral language and no verbal suggestion consisting of 1 rep of wall squat, 3 min or to volitional fatigue at 100° knee angle;(n=30).Group 2: Isometric exercise with neutral language and no verbal suggestion consisting of 3 reps of wall squat, 3 min or to volitional fatigue at 100°degree knee angle, 30 sec rest between rep, ;(n=30).Group 3 (Control group): true control (do nothing);(n=30).

Inclusion Criteria:Aged 18 years or older.Diagnosed with unilateral or bilateral symptomatic knee OA.Have chronic knee pain for three months and more.Able to perform physical therapy exercise.Exclusion Criteria:Pregnancy.Severe musculoskeletal or neuromuscular disorders or any disease that prevent performing exercises.Uncontrolled diabetes.Knee or lower limb surgery.Sensations problems.Orthopedic impairment (e.g., balance problems and Fractures in lower limb in the last 6 months).